SuperPRP: Enhancing PRP Injections with Plasma Proteins and Hyaluronic Acid

Using the patient's own blood, PRP Therapy has proven to be a safe and effective treatment for joint pain.

Platelet-Rich Plasma (PRP) Therapy has become a cornerstone in regenerative medicine, celebrated for its ability to stimulate healing and reduce inflammation. As clinical experience evolves, researchers and clinicians are finding ways to amplify PRP's therapeutic potential, to patients benefit. Most recently, SuperPRP has been created by incorporating plasma proteins, autologous fibrin, and hyaluronic acid to boost its efficacy.

How It Works

PRP is rich in growth factors released by platelets, but its efficacy depends on the surrounding environment. Plasma proteins like fibrinogen, fibronectin, and vitronectin naturally support tissue repair and serve as scaffolding for cell migration. When these proteins are concentrated and combined with PRP, they enhance the biological signaling that directs tissue regeneration. Autologous fibrin, derived from a patient's own blood, acts as a three-dimensional matrix that holds platelets and growth factors at the injury site longer. This controlled release sustains the regenerative effect over time, rather than the brief boost often seen with standard PRP injections. The result is improved cellular recruitment, angiogenesis, and collagen formation, which are crucial in healing ligaments, tendons, and soft tissues.

This combination is sometimes referred to as "PRP plus fibrin matrix" or "plasma gel PRP", and is gaining popularity in orthopedics, sports medicine, and aesthetic medicine for its enhanced regenerative outcomes. 

PRP + hyaluronic acid can be used to increase healing in patients with joint arthritis.

We can also boost PRP effectiveness by mixing in hyaluronic acid, a well studied joint lubricant. With very little side effects, hyaluronic acid adds a mechanical advantage to the injection by lubricating the joint and providing an added cushion.  Studies have shown this practice to be very safe, and it's been shown to work better than solely hyaluronic acid or solely PRP for the treatment of joint arthritis (for example, in knees, hips, and shoulders). 

What SuperPRP Means for Patients

By leveraging the body's own healing elements in a more structured and sustained delivery system, clinicians can significantly improve patient results. As research continues, integrating plasma proteins and fibrin with PRP may become the new gold standard in biologic therapies.